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减重手术袖状胃切除术后因维生素A缺乏导致孕期夜盲症:一例报告

Nyctalopia during pregnancy due to vitamin A deficiency after bariatric sleeve gastrectomy: A case report.

作者信息

Anastasakis Eleftherios, Anastasakis Anastasios, Samara Athina A, Koutras Antonios, Fasoulakis Zacharias, Zikopoulos Athanasios, Skentou Chara, Sotiriou Sotirios

机构信息

Department of Obstetrics and Gynecology Iaso Maternity Hospital Athens Greece.

Department of Ophthalmology Athens Eye Hospital Athens Greece.

出版信息

Clin Case Rep. 2024 Sep 6;12(9):e9387. doi: 10.1002/ccr3.9387. eCollection 2024 Sep.

DOI:10.1002/ccr3.9387
PMID:39247563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377988/
Abstract

KEY CLINICAL MESSAGE

Herein, we report a rare case of nyctalopia diagnosed in the first trimester of pregnancy due to vitamin A deficiency as a result of a bariatric gastrectomy. Low serum vitamin A levels establish the diagnosis and the patient was treated with oral vitamin A supplements. Moreover, due to the teratogenic effects of exceed Vitamin A levels in early pregnancy, supplements' dosages should be prescribed with respect to the safe limits. Our case aims to highlight the importance of checking micronutricients and vitamins levels before and during pregnancy in women that had a previous bariatric surgery.

ABSTRACT

Vitamin A deficiency (VAD) has been identified as the predominant factor in the development of night blindness during pregnancy, a high-risk for morbidity situation. Herein, we report a rare case of nyctalopia diagnosed in the first trimester of pregnancy due to VAD as a result of a bariatric gastrectomy. Our case aims to highlight the importance of checking micronutricients and vitamins levels before and during pregnancy in women that had a previous bariatric surgery. Low serum vitamin A levels establish the diagnosis and the patient was treated with oral vitamin A supplements. An uneventful antenatal course resulted in the birth of a healthy live neonatal at 38 weeks of gestation. In conclusion, nyctalopia is a rare condition in pregnant women that is often caused by VAD that poses significant health risks for both the mother and the infant, especially in women with a history of gastrointestinal bypass surgery, or any factors leading to malnutrition. Clinicians have to be alerted for micronutrients deficient in pregnant women who have a bariatric operation in their medical history.

摘要

关键临床信息

在此,我们报告一例罕见的夜盲症病例,该病例发生在妊娠早期,是由于减肥胃切除术后维生素A缺乏所致。血清维生素A水平低有助于确诊,患者接受了口服维生素A补充剂治疗。此外,由于孕早期维生素A水平过高具有致畸作用,补充剂的剂量应按照安全限度来开具。我们的病例旨在强调对于既往接受过减肥手术的女性,在怀孕前和怀孕期间检查微量营养素和维生素水平的重要性。

摘要

维生素A缺乏(VAD)已被确定为孕期夜盲症发展的主要因素,这是一种高发病风险情况。在此,我们报告一例罕见的夜盲症病例,该病例发生在妊娠早期,是由于减肥胃切除术后维生素A缺乏所致。我们的病例旨在强调对于既往接受过减肥手术的女性,在怀孕前和怀孕期间检查微量营养素和维生素水平的重要性。血清维生素A水平低有助于确诊,患者接受了口服维生素A补充剂治疗。孕期过程顺利,在妊娠38周时产下一名健康的活产新生儿。总之,夜盲症在孕妇中是一种罕见病症,通常由维生素A缺乏引起,这对母亲和婴儿都构成重大健康风险,尤其是对于有胃肠道旁路手术史或任何导致营养不良因素的女性。临床医生必须警惕有减肥手术病史的孕妇存在的微量营养素缺乏情况。

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本文引用的文献

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Vitamin A-Mediated Birth Defects: A Narrative Review.维生素A介导的出生缺陷:一篇叙述性综述
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Nyctalopia: the sequelae of hypovitaminosis A.夜盲症:维生素A缺乏症的后遗症。
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