人红细胞乙酰胆碱酯酶在健康和疾病中的作用。
Human Erythrocyte Acetylcholinesterase in Health and Disease.
机构信息
Instituto de Bioquímica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal.
出版信息
Molecules. 2017 Sep 8;22(9):1499. doi: 10.3390/molecules22091499.
Abstract
The biochemical properties of erythrocyte or human red blood cell (RBC) membrane acetylcholinesterase (AChE) and its applications on laboratory class and on research are reviewed. Evidence of the biochemical and the pathophysiological properties like the association between the RBC AChE enzyme activity and the clinical and biophysical parameters implicated in several diseases are overviewed, and the achievement of RBC AChE as a biomarker and as a prognostic factor are presented. Beyond its function as an enzyme, a special focus is highlighted in this review for a new function of the RBC AChE, namely a component of the signal transduction pathway of nitric oxide.
摘要
本文综述了红细胞或人红细胞（RBC）膜乙酰胆碱酯酶（AChE）的生化特性及其在实验室和研究中的应用。本文综述了其生化和病理生理学特性的证据，如 RBC AChE 酶活性与几种疾病相关的临床和生物物理参数之间的关联，以及 RBC AChE 作为生物标志物和预后因素的作用。除了作为一种酶的功能外，本文特别强调了 RBC AChE 的一个新功能，即作为一氧化氮信号转导途径的组成部分。
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