鹌鹑、鸭、鹅、鸡、火鸡和大鼠中含细胞色素P - 450的肝微粒体酶对药物代谢的比较研究。

Studies on comparative drug metabolism by hepatic cytochrome P-450-containing microsomal enzymes in quail, ducks, geese, chickens, turkeys and rats.

Dalvi R R, Nunn V A, Juskevich J

Department of Physiology and Pharmacology, School of Veterinary Medicine, Tuskegee University, AL 36088.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(2):421-4. doi: 10.1016/0742-8413(87)90030-2.

Abstract

These studies were carried out to compare certain hepatic microsomal drug-metabolizing enzymes of quail, ducks, geese, chickens, turkeys and rats. 2. Comparison of relative liver weights of the species indicated that the rats had the largest weight followed by turkeys, ducks, geese, chickens and quail. 3. Rats ranked highest in hepatic cytochrome P-450 content followed in decreasing order by turkeys, geese, chickens, ducks and quail. 4. Microsomal benzphetamine N-demethylase activity was significantly higher in geese and turkeys than that for the rest of the species. 5. Geese, chickens and turkeys showed similar aniline hydroxylase activity, while it was markedly lower in quail and ducks with rats being intermediate.

摘要

开展这些研究是为了比较鹌鹑、鸭、鹅、鸡、火鸡和大鼠的某些肝微粒体药物代谢酶。2. 对这些物种的相对肝脏重量进行比较表明，大鼠的肝脏重量最大，其次是火鸡、鸭、鹅、鸡和鹌鹑。3. 大鼠肝脏细胞色素P - 450含量最高，其次是火鸡、鹅、鸡、鸭和鹌鹑，呈递减顺序。4. 微粒体苄非他明N - 脱甲基酶活性在鹅和火鸡中显著高于其他物种。5. 鹅、鸡和火鸡表现出相似的苯胺羟化酶活性，而鹌鹑和鸭中的活性明显较低，大鼠的活性介于两者之间。