Verney E, Wang D, Sidransky H
Department of Pathology, George Washington University Medical Center, Washington, DC 20037.
Exp Mol Pathol. 1987 Oct;47(2):279-89. doi: 10.1016/0014-4800(87)90081-5.
The influence of varying the dietary protein content on the emergence of gamma-glutamyl transpeptidase (GGT)-positive foci in the livers of male rats fed elevated (2%) L-tryptophan (TRP) after being exposed to a hepatocarcinogen was investigated. Subtotal hepatectomies were performed, and 18 hr later the rats were treated with diethylnitrosamine (30 mg/kg). Ten days later four dietary groups were followed for 10 weeks: (1) control diet containing 21% protein (C); (2) control diet containing 5.3% protein (C-LP); (3) C + TRP; and (4) C-LP + TRP. Rats fed the C-LP diet developed heavier livers but fewer and smaller GGT + foci than did rats fed the C diet. Rats fed elevated TRP diets (C + TRP and C-LP + TRP) developed more and larger GGT + foci than did rats fed the regular control diets (C and C-LP), indicating that the promotional effect of elevated dietary TRP was similar at the two levels of dietary protein.
研究了改变膳食蛋白质含量对暴露于致癌物后喂食高剂量（2%）L-色氨酸（TRP）的雄性大鼠肝脏中γ-谷氨酰转肽酶（GGT）阳性病灶出现的影响。进行了次全肝切除术，18小时后用二乙基亚硝胺（30mg/kg）处理大鼠。10天后，四个饮食组持续观察10周：（1）含21%蛋白质的对照饮食（C）；（2）含5.3%蛋白质的对照饮食（C-LP）；（3）C + TRP；（4）C-LP + TRP。喂食C-LP饮食的大鼠肝脏比喂食C饮食的大鼠更重，但GGT+病灶更少、更小。喂食高剂量TRP饮食（C + TRP和C-LP + TRP）的大鼠比喂食常规对照饮食（C和C-LP）的大鼠出现更多、更大的GGT+病灶，表明在两种膳食蛋白质水平下，高剂量膳食TRP的促进作用相似。
