Wong Li Ping, Alias Haridah, Hassan Jamiyah, AbuBakar Sazaly
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Julius Centre University of Malaya (JCUM), University of Malaya, 50603 Kuala Lumpur, Malaysia; Tropical Infectious Diseases Research and Educational Centre (TIDREC), University of Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Vaccine. 2017 Oct 13;35(43):5912-5917. doi: 10.1016/j.vaccine.2017.08.074. Epub 2017 Sep 5.
The aim of this study was to examine the willingness of pregnant women to have prenatal screening for the Zika virus (ZIKV). Secondly, the study also assessed the acceptability of a hypothetical Zika vaccination and its association with the health belief model (HBM) constructs. A cross-sectional study was conducted from 4th October to 11th November 2016, among pregnant women who attended antenatal care at the University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. The majority (81.8%) was willing to be tested for ZIKV and 78% felt that their spouse would be willing to be tested for ZIKV. A total of 94% expressed a willingness to receive a Zika vaccination if available. The participants expressed high perceived benefits of a ZIKV vaccination. Although many have a high perception of the severity of ZIKV, the proportion with a strong perception of their susceptibility to ZIKV was low. In the multivariate analysis of all the HBM constructs, cue-to-action, namely physician recommendation (odds ratio [OR]=2.288; 95% confidence interval [CI] 1.093-4.793) and recommendation from friends or relatives (OR=4.030; 95% CI 1.694-9.587), were significantly associated with a willingness to be vaccinated against ZIKV. The favourable response to a Zika vaccination implies that more research attention has to be given to develop a vaccine against ZIKV. Should the vaccine be available in the future, publicity and healthcare providers would play a vital role in ensuring vaccine uptake among pregnant women.
本研究的目的是调查孕妇进行寨卡病毒（ZIKV）产前筛查的意愿。其次，该研究还评估了一种假设的寨卡疫苗的可接受性及其与健康信念模型（HBM）各要素的关联。2016年10月4日至11月11日，在马来西亚吉隆坡马来亚大学医学中心（UMMC）接受产前护理的孕妇中进行了一项横断面研究。大多数（81.8%）孕妇愿意接受ZIKV检测，78%的孕妇认为其配偶愿意接受ZIKV检测。共有94%的孕妇表示愿意在有疫苗的情况下接种寨卡疫苗。参与者对ZIKV疫苗的益处感知较高。尽管许多人对ZIKV的严重性有较高认知，但对自身感染ZIKV易感性有强烈认知的比例较低。在对所有HBM要素的多变量分析中，行动提示，即医生建议（优势比[OR]=2.288；95%置信区间[CI] 1.093 - 4.793）和朋友或亲属的建议（OR=4.030；95% CI 1.694 - 9.587），与接种ZIKV疫苗的意愿显著相关。对寨卡疫苗的积极反应意味着必须给予更多研究关注来研发针对ZIKV的疫苗。如果未来有该疫苗，宣传和医疗保健提供者将在确保孕妇接种疫苗方面发挥至关重要的作用。
