State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China.
Clin Exp Ophthalmol. 2018 May;46(4):356-363. doi: 10.1111/ceo.13058. Epub 2017 Oct 10.
Intraocular lens (IOL) power selection is a critical factor affecting visual outcome after IOL implantation in short eyes. Many formulas have been developed to achieve a precise prediction of the IOL power. However, controversy regarding the accuracy remains.
To investigate the accuracy of different IOL power calculation formulas in short eyes.
Meta-analysis.
Patients with the axial length of eyes less than 22 mm from previously reported studies.
A comprehensive search in Pubmed, EMBASE, Cochrane Data Base of Systematic Reviews and the Cochrane Central Register of Controlled Trials was conducted by October 2016. We assessed the methodological quality using a modified QUADAS-2 tool and performed analysis on weighted mean differences of mean absolute errors (MAE) among different formulas.
The between-group difference of MAE was evaluated with weighted mean difference and 95% confidence intervals.
Ten observational studies, involving 1161 eyes, were enrolled to compare six formulas: Haigis, Holladay 2, Hoffer Q, Holladay 1, SRK/T and SRK II. Among them, the Holladay 2 introduced the smallest overall MAE (0.496D) without statistical significance. The difference of MAE is statistically significant between Haigis and Hoffer Q (mean difference = -0.07D, P = 0.003), Haigis and SRK/T (mean difference = -0.07D, P = 0.009), Haigis and SRK II (mean difference = -0.41D, P = 0.01). For publication bias and small-study effect, neither funnel plot nor egger's test detected statistical finding.
The overall evidence from the studies confirmed the superiority of Haigis over Hoffer Q, SRK/T and SRK II in prediction IOL power in short eyes.
人工晶状体（IOL）的屈光力选择是影响短眼患者 IOL 植入术后视力结果的关键因素。已经开发出许多公式来实现 IOL 屈光力的精确预测。然而，关于准确性的争议仍然存在。
研究不同 IOL 屈光力计算公式在短眼中的准确性。
荟萃分析。
来自先前报道的研究中眼轴长度小于 22mm 的患者。
通过 2016 年 10 月对 Pubmed、EMBASE、Cochrane 系统评价数据库和 Cochrane 对照试验中心注册进行全面检索。我们使用改良的 QUADAS-2 工具评估方法学质量，并对不同公式之间平均绝对误差（MAE）的加权均数差异进行分析。
采用加权均数差值和 95%置信区间评估组间 MAE 的差异。
共纳入 10 项观察性研究，共涉及 1161 只眼，比较了 6 种公式：Haigis、Holladay 2、Hoffer Q、Holladay 1、SRK/T 和 SRK II。其中，Holladay 2 引入的总体 MAE 最小（0.496D），但无统计学意义。Haigis 和 Hoffer Q（均数差值=-0.07D，P=0.003）、Haigis 和 SRK/T（均数差值=-0.07D，P=0.009）、Haigis 和 SRK II（均数差值=-0.41D，P=0.01）之间的 MAE 差异有统计学意义。对发表偏倚和小样本效应进行漏斗图和 egger 检验，均未发现统计学结果。
这些研究的综合证据证实，Haigis 在预测短眼患者 IOL 屈光力方面优于 Hoffer Q、SRK/T 和 SRK II。
