Department of Urology Surgery, Third Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China; Department of Urology, Heilongjiang Provincial Hospital, Harbin 150036, PR China.
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, Heilongjiang University, Harbin 150080, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:252-260. doi: 10.1016/j.msec.2017.08.020. Epub 2017 Aug 4.
The black TiO nanoparticles are synthesized via a facile calcination method combined with an in-situ controllable solid-state reaction approach. The results indicate that the photocatalyst with a narrow band gap of ~2.32 eV extends the photoresponse to visible light and near infrared region. And thus more reactive oxygen species can be obtained to induce the cell-killing under 808 nm light triggering. The as-obtained black TiO nanoparticles exhibiting low toxicity, good biocompatibility and high anticancer effect in vitro, is demonstrated as efficient photosensitizers for phototherapy to kill the bladder cancer cells. These findings suggest that the facile synthetic black TiO nanomaterials will have broad application in biomedicine.
黑色 TiO 纳米粒子是通过一种简便的煅烧方法与原位可控固态反应方法合成的。结果表明，具有~2.32 eV 窄带隙的光催化剂将光响应扩展到可见光和近红外区域。因此，可以获得更多的活性氧物质，在 808nm 光触发下诱导细胞杀伤。所获得的黑色 TiO 纳米粒子表现出低毒性、良好的生物相容性和体外高抗癌效果，被证明是用于杀死膀胱癌细胞的光疗的有效光敏剂。这些发现表明，简便合成的黑色 TiO 纳米材料将在生物医学中有广泛的应用。
