D-1多巴胺受体对B-HT 920诱导的大鼠抽搐的抑制作用。
Inhibitory role of D-1 dopamine receptors for the jerks induced by B-HT 920 in rats.
作者信息
Grabowska-Andén M, Andén N E
机构信息
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
出版信息
J Pharm Pharmacol. 1987 Aug;39(8):660-1. doi: 10.1111/j.2042-7158.1987.tb03450.x.
Jerks of the head and upper trunk produced by the dopamine agonist B-HT 920 in reserpine-treated rats were abolished by the D-1 dopamine receptor agonist SKF 38393. The combined treatment with SKF 38393 and B-HT 920 instead resulted in stereotypies and locomotion. B-HT 920 also caused jerks when given after the D-1 receptor antagonist SCH 23390 to rats not pretreated with reserpine. The results indicate that B-HT 920 induces jerks by stimulation of postsynaptic D-2-like dopamine receptors provided that the D-1 receptors are not activated.
多巴胺激动剂B-HT 920在利血平处理的大鼠中所引发的头部和上躯干抽搐，被D-1多巴胺受体激动剂SKF 38393消除。相反，SKF 38393与B-HT 920联合治疗则导致刻板行为和运动。在未用利血平预处理的大鼠中，给其注射D-1受体拮抗剂SCH 23390后再给予B-HT 920，B-HT 920也会引发抽搐。结果表明，只要D-1受体未被激活，B-HT 920通过刺激突触后D-2样多巴胺受体来诱发抽搐。
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