Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.

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作者信息

Pifl C, Hornykiewicz O

机构信息

Institute of Biochemical Pharmacology, University of Vienna, Austria.

出版信息

Eur J Pharmacol. 1988 Jan 27;146(1):189-91. doi: 10.1016/0014-2999(88)90504-3.

DOI:10.1016/0014-2999(88)90504-3

PMID:3258244

Abstract

摘要

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Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.

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Is stimulation of both D1 and D2 receptors necessary for the expression of dopamine-mediated behaviors?多巴胺介导的行为表达是否需要同时刺激 D1 和 D2 受体？

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Evidence for postsynaptic dopamine agonist effects of B-HT 920 in the presence of the dopamine D-1 agonist SKF 38393.在多巴胺D-1激动剂SKF 38393存在的情况下，B-HT 920的突触后多巴胺激动剂效应的证据。

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Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats.多巴胺D1和D2受体的相对亲和力和效能决定了多巴胺激动剂是否会在大鼠中诱发多动或口部刻板行为。

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Obligatory D-1/D-2 receptor interaction in the generation of dopamine agonist related behaviors.多巴胺激动剂相关行为产生中D-1/D-2受体的强制性相互作用。

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D1 dopamine receptor activation required for postsynaptic expression of D2 agonist effects.D2激动剂效应的突触后表达需要D1多巴胺受体激活。

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B-HT 920 is a full agonist at both pre- and postsynaptic D-2 dopamine receptors.B-HT 920对突触前和突触后D-2多巴胺受体均为完全激动剂。

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