An Hyeong Su, Moon Won-Jin, Ryu Jae-Kyun, Park Ju Yeon, Yun Won Sung, Choi Jin Woo, Jahng Geon-Ho, Park Jang-Yeon
Department of Radiology, Konkuk University School of Medicine, Republic of Korea.
Department of Radiology, Konkuk University School of Medicine, Republic of Korea.
Magn Reson Imaging. 2017 Dec;44:125-130. doi: 10.1016/j.mri.2017.09.001. Epub 2017 Sep 6.
This prospective multi-center study aimed to evaluate the inter-vendor and test-retest reliabilities of resting-state functional magnetic resonance imaging (RS-fMRI) by assessing the temporal signal-to-noise ratio (tSNR) and functional connectivity. Study included 10 healthy subjects and each subject was scanned using three 3T MR scanners (GE Signa HDxt, Siemens Skyra, and Philips Achieva) in two sessions. The tSNR was calculated from the time course data. Inter-vendor and test-retest reliabilities were assessed with intra-class correlation coefficients (ICCs) derived from variant component analysis. Independent component analysis was performed to identify the connectivity of the default-mode network (DMN). In result, the tSNR for the DMN was not significantly different among the GE, Philips, and Siemens scanners (P=0.638). In terms of vendor differences, the inter-vendor reliability was good (ICC=0.774). Regarding the test-retest reliability, the GE scanner showed excellent correlation (ICC=0.961), while the Philips (ICC=0.671) and Siemens (ICC=0.726) scanners showed relatively good correlation. The DMN pattern of the subjects between the two sessions for each scanner and between three scanners showed the identical patterns of functional connectivity. The inter-vendor and test-retest reliabilities of RS-fMRI using different 3T MR scanners are good. Thus, we suggest that RS-fMRI could be used in multicenter imaging studies as a reliable imaging marker.
这项前瞻性多中心研究旨在通过评估静息态功能磁共振成像（RS-fMRI）的时间信噪比（tSNR）和功能连接性，来评价不同厂商设备之间以及重测的可靠性。研究纳入了10名健康受试者，每位受试者在两个阶段使用三台3T磁共振成像扫描仪（GE Signa HDxt、西门子Skyra和飞利浦Achieva）进行扫描。tSNR由时间序列数据计算得出。通过变异成分分析得出的组内相关系数（ICC）来评估不同厂商设备之间以及重测的可靠性。进行独立成分分析以识别默认模式网络（DMN）的连接性。结果显示，GE、飞利浦和西门子扫描仪之间DMN的tSNR无显著差异（P = 0.638）。就厂商差异而言，不同厂商设备之间的可靠性良好（ICC = 0.774）。关于重测可靠性，GE扫描仪显示出极佳的相关性（ICC = 0.961），而飞利浦（ICC = 0.671）和西门子（ICC = 0.726）扫描仪显示出相对良好的相关性。每位受试者在每个扫描仪的两个阶段之间以及三台扫描仪之间的DMN模式显示出相同的功能连接模式。使用不同3T磁共振成像扫描仪的RS-fMRI在不同厂商设备之间以及重测的可靠性良好。因此，我们建议RS-fMRI可作为一种可靠的成像标志物用于多中心成像研究。
