Hayashi M, Kimura J, Oh-Ishi S, Tsushima S, Nomura H
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Jpn J Pharmacol. 1987 Jun;44(2):127-34. doi: 10.1254/jjp.44.127.
CV-3988 inhibited the vascular permeability increase induced by C16-PAF and C18-PAF in rat skin in a dose-dependent manner. The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: parallel shift of the dose-response curve; crossing of double reciprocal plots on the intersection of the ordinate; and no inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC4. PAF-induced blood pressure fall in rats was also suppressed by pretreatment with CV-3988 selectively.
CV - 3988以剂量依赖性方式抑制C16 - PAF和C18 - PAF诱导的大鼠皮肤血管通透性增加。通过以下观察结果表明这种抑制是特异性的，并且在其受体上与PAF具有竞争性：剂量 - 反应曲线的平行移动；双倒数图在纵坐标交点处交叉；对其他自分泌物质如缓激肽、组胺、5 - 羟色胺和LTC4没有抑制作用。用CV - 3988预处理也选择性地抑制了PAF诱导的大鼠血压下降。
