Qu X F, Hayashi M, Yamaki K, Oh-ishi S
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Jpn J Pharmacol. 1990 Mar;52(3):500-3. doi: 10.1254/jjp.52.500.
Vascular permeability increase induced by histamine, bradykinin, platelet-activating factor (PAF), or phorbol myristate acetate (PMA) in the mouse paw was assessed by the dye leakage method. The amount of dye extracted from the paw showed a clear dose-response relationship to the dose of each agonist injected into the paw. Among the autacoids used, PAF showed the most potent activity in the mouse paw. The results are consistent with those seen in the rat dorsal skin as previously reported. Involvement of histamine, 5-hydroxytryptamine and PAF is suggested in the vascular permeability increase induced by PMA in the mouse paw.
通过染料渗漏法评估组胺、缓激肽、血小板活化因子（PAF）或佛波醇肉豆蔻酸酯乙酸酯（PMA）诱导的小鼠爪部血管通透性增加。从小鼠爪部提取的染料量与注入爪部的每种激动剂剂量呈明显的剂量反应关系。在所使用的自分泌物质中，PAF在小鼠爪部表现出最强的活性。结果与先前报道的大鼠背部皮肤实验结果一致。提示组胺、5-羟色胺和PAF参与了PMA诱导的小鼠爪部血管通透性增加。
