Magouliotis Dimitrios E, Tasiopoulou Vasiliki S, Svokos Alexis A, Svokos Konstantina A, Chatedaki Christina, Sioka Eleni, Zacharoulis Dimitris
Department of Surgery, University Hospital of Larissa, Viopolis, 411 10, Larissa, Greece.
Faculty of Medicine, School of Health Sciences, University of Thessaly Viopolis Larissa Greece, Viopolis, Larissa, Greece.
Obes Surg. 2017 Nov;27(11):3021-3030. doi: 10.1007/s11695-017-2924-y.
We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis reported fewer cases of gallstone disease in the UDCA group in relation to different bariatric procedures, doses of administered UDCA, and time from bariatric surgery. Adverse events were similar in both groups. Fewer patients required cholecystectomy in UDCA group. No deaths were reported. The administration of UDCA after bariatric surgery seems to prevent gallstone formation.
我们旨在回顾关于肥胖患者接受熊去氧胆酸（UDCA）治疗以预防减肥手术后胆结石形成的现有文献。根据PRISMA指南，在PubMed、Cochrane图书馆和Scopus数据库中进行了系统的文献检索。八项研究符合纳入标准，共纳入1355例患者。随机效应荟萃分析显示，服用UDCA的患者胆结石形成的发生率较低。亚组分析报告，在UDCA组中，与不同的减肥手术、UDCA给药剂量以及减肥手术后的时间相关的胆结石疾病病例较少。两组的不良事件相似。UDCA组需要进行胆囊切除术的患者较少。未报告死亡病例。减肥手术后给予UDCA似乎可以预防胆结石形成。
