Ahtee L, Attila L M
Department of Pharmacy, University of Helsinki, Finland.
Med Biol. 1987;65(2-3):113-9.
The functioning of cerebral monoaminergic neurons is altered during withdrawal from morphine. Our results suggest that the functioning of cerebral dopaminergic and possibly 5HTergic neurons might be regulated by opioid mechanisms and these neurons may be important in the reinforcing and rewarding effects of morphine. The limbic dopaminergic neurons seem to be more vulnerable to chronic opioid administration than the striatal ones. The cerebral noradrenergic neurons seem to be linked with physical signs and symptoms of opioid withdrawal.
在吗啡戒断期间，脑内单胺能神经元的功能会发生改变。我们的结果表明，脑内多巴胺能神经元以及可能的5-羟色胺能神经元的功能可能受阿片类机制调控，并且这些神经元在吗啡的强化和奖赏效应中可能起重要作用。与纹状体多巴胺能神经元相比，边缘系统的多巴胺能神经元似乎对慢性阿片类药物给药更敏感。脑内去甲肾上腺素能神经元似乎与阿片类戒断的体征和症状有关。
