Ghosh S, Patel A H, Cousins M, Grasing K
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903, USA.
Neurochem Res. 1998 Jun;23(6):875-85. doi: 10.1023/a:1022463029351.
The purpose of these experiments was to further characterize changes in dopaminergic function that follow withdrawal from chronic opiate treatment. Withdrawal after treatment to a maximum dose of 120 mg/kg of morphine did not alter dopamine concentrations in the substantia nigra, ventral tegmental area, striatum, or nucleus accumbens; but did decrease concentrations of DOPAC and the ratio of DOPAC to dopamine in the lateral striatum and nucleus accumbens. Uptake of tritiated dopamine was diminished for withdrawn slices obtained from the striatum with no effect observed for tissue from the nucleus accumbens. Deficits of in vitro release of tritiated dopamine also occurred following withdrawal, with the nucleus accumbens being sensitive to dependence produced by a lower dose of morphine. In conclusion, opiate withdrawal produces a complex pattern of effects on dopaminergic function that is specific for the striatum and nucleus accumbens.
这些实验的目的是进一步描述长期阿片类药物治疗戒断后多巴胺能功能的变化。给予最大剂量为120mg/kg吗啡治疗后戒断，并未改变黑质、腹侧被盖区、纹状体或伏隔核中的多巴胺浓度；但确实降低了外侧纹状体和伏隔核中3,4-二羟基苯乙酸（DOPAC）的浓度以及DOPAC与多巴胺的比率。从纹状体获得的戒断切片中，氚标记多巴胺的摄取减少，而伏隔核组织未观察到影响。戒断后也出现了氚标记多巴胺体外释放的缺陷，伏隔核对较低剂量吗啡产生的依赖性敏感。总之，阿片类药物戒断对多巴胺能功能产生了复杂的影响模式，这对纹状体和伏隔核具有特异性。
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