"Lino Rossi" Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy.
"Lino Rossi" Research Center for the Study and Prevention of Unexpected Perinatal Death and SIDS, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy.
Mitochondrion. 2018 May;40:13-15. doi: 10.1016/j.mito.2017.09.001. Epub 2017 Sep 8.
In literature there are no data related to mitochondrial DNA (mtDNA) content in sudden intrauterine unexplained death syndrome (SIUDS). To test the hypothesis that a quantitative excess of mtDNA could play a role in the pathogenesis of SIUDS, mtDNA content was measured in cerebral cortex of 9 SIUDS and in 7 controls. The median (interquartile range) mtDNA in SIUDS and controls was 14,000 (8600-33,500), 3400 (0-8500) copies per nuclear DNA, respectively (p=0.007). If mitochondria are involved in SIUDS, then higher mitochondrial DNA content may be a biomarker of this syndrome.
文献中没有关于线粒体 DNA（mtDNA）含量与突发性宫内原因不明死亡综合征（SIUDS）的相关数据。为了验证mtDNA 含量过量可能在 SIUDS 发病机制中起作用的假设，我们测量了 9 例 SIUDS 和 7 例对照者大脑皮层中的 mtDNA 含量。SIUDS 和对照组的 mtDNA 中位数（四分位间距）分别为 14000（8600-33500）和 3400（0-8500）拷贝/核 DNA（p=0.007）。如果线粒体参与了 SIUDS，那么更高的线粒体 DNA 含量可能是该综合征的生物标志物。
