Department of Biomedical Sciences and Public Health, University Politecnica delle Marche, 60126 Ancona, Italy.
Department of Medical Sciences, Section of Legal Medicine, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy.
Cells. 2024 Aug 13;13(16):1347. doi: 10.3390/cells13161347.
Intrauterine fetal death and perinatal death represent one of the most relevant medical scientific problems since, in many cases, even after extensive investigation, the causes remain unknown. The considerable increase in medical legal litigation in the obstetrical field that has witnessed in recent years, especially in cases of stillborn births, has simultaneously involved the figure of the forensic pathologist in scientific research aimed at clarifying the pathophysiological processes underlying stillbirth.
our study aims to analyze cases of sudden intrauterine unexplained death syndrome (SIUD) to evaluate the role of oxidative stress in the complex pathogenetic process of stillbirth. In particular, the immunohistochemical expression of specific oxidative stress markers (NOX2, NT, iNOS, 8-HODG, IL-6) was evaluated in tissue samples of placentas of SIUDs belonging to the extensive case series (20 cases), collected from autopsy cases of the University of Ferrara and Politecnica delle Marche between 2017 and 2023.
The study demonstrated the involvement of oxidative stress in intrauterine fetal deaths in the placenta of the cases examined. In SIUD, the most expressed oxidative stress markers were NOX2 and 8-HODG.
The study contributes to investigating the role of oxidative stress in modulating different pathways in unexplained intrauterine fetal death (SIUD) tissues.
宫内胎儿死亡和围产儿死亡是最相关的医学科学问题之一，因为在许多情况下，即使进行了广泛的调查，原因仍然未知。近年来，产科领域的医疗法律诉讼显著增加，尤其是在死产病例中，法医病理学家也同时参与了旨在阐明死产背后病理生理过程的科学研究。
我们的研究旨在分析不明原因的突发性宫内胎儿死亡综合征（SIUD）病例，以评估氧化应激在死产复杂发病机制中的作用。特别地，我们评估了来自 2017 年至 2023 年费拉拉大学和马尔凯理工大学尸检案例的广泛案例系列（20 例）中 SIUD 胎盘组织样本中特定氧化应激标志物（NOX2、NT、iNOS、8-HODG、IL-6）的免疫组织化学表达。
该研究表明氧化应激参与了所检查病例胎盘内的宫内胎儿死亡。在 SIUD 中，表达最丰富的氧化应激标志物是 NOX2 和 8-HODG。
该研究有助于研究氧化应激在调节不明原因宫内胎儿死亡（SIUD）组织中不同途径的作用。
