Dermatology Unit, Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy; Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy.
Dermatology Unit, Department of Specialised, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy.
Photodiagnosis Photodyn Ther. 2017 Dec;20:107-110. doi: 10.1016/j.pdpdt.2017.09.004. Epub 2017 Sep 7.
Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University.
We retrospectively analysed MF patients treated with PDT over the last ten years. Each PDT protocol consisted of the appliance for 3h under an occlusive film dressing on each lesion of a one-mm-thick layer of 16% methyl aminolaevulinate (MAL) 160mg/g cream (Metvix, Galderma, Paris, France). The cream was then removed and the skin was exposed to 630nm red light from a diode lamp (Aktilite, Galderma Benelux, Rotterdam, the Netherlands), with a total radiation dose of 37J/cm2 for 9 mins. A protocol of one session every month was scheduled. The treated lesions were clinically examined, before each treatment.
Four cases, three male and one female, had been treated with PDT. Two patch lesions on the plantar area, one leg and the pubic area were treated. The number of PDT sessions ranged from 4 to 9. Two complete remissions and two partial remissions were observed. A low-to-mild burning sensation was reported during the treatment, and persisted over the next day; no further side effects were observed.
Our series shows that PDT can be considered an effective second-line treatment in patients characterised by a disease located in difficult-to-treat anatomical areas such as the feet and the pubic area.
光动力疗法（PDT）是一种众所周知且有效的非黑素瘤皮肤癌治疗方法。许多研究也表明其在蕈样肉芽肿中的有效性。本研究的目的是分析在博洛尼亚大学皮肤科接受 PDT 治疗的 MF 患者。
我们回顾性分析了过去十年中接受 PDT 治疗的 MF 患者。每个 PDT 方案包括在每个病变部位涂抹 16%甲基氨基酮戊酸（MAL）160mg/g 乳膏（Metvix，Galderma，巴黎，法国），厚度为 1 毫米，然后用不透气膜敷料覆盖 3 小时。然后去除乳膏，将皮肤暴露于二极管灯（Aktilite，Galderma Benelux，鹿特丹，荷兰）发出的 630nm 红光下，总辐射剂量为 37J/cm2，持续 9 分钟。计划每月进行一次治疗方案。在每次治疗前，对治疗的病变部位进行临床检查。
有 4 例患者，3 例男性，1 例女性，接受了 PDT 治疗。治疗了足底、腿部和阴部的 2 个斑块病变。 PDT 治疗次数从 4 次到 9 次不等。观察到 2 例完全缓解和 2 例部分缓解。治疗过程中报告有轻度至中度烧灼感，并持续到第二天；未观察到其他副作用。
我们的系列研究表明，对于位于足部和阴部等难以治疗的解剖区域的疾病患者，PDT 可被视为一种有效的二线治疗方法。
