Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Clin Nutr. 2018 Oct;37(5):1541-1549. doi: 10.1016/j.clnu.2017.08.021. Epub 2017 Aug 30.
Few studies have examined the associations of serum magnesium (Mg) concentrations with total and cause-specific mortality in a nationally representative sample of US adults. We investigate the dose-response relationships of baseline serum Mg concentrations with risk of mortalities in a large, nationally representative sample of US adults.
We analyzed prospective data of 14,353 participants aged 25-74 years with measures of serum Mg concentrations at baseline (1971-1975) from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (NHEFS). Mortality data was linked through December 31, 2011. We estimated the mortality hazard ratios (HRs), for participants within serum Mg categories of <0.7, 0.7-0.74, 0.75-0.79, 0.8-0.89 (referent), 0.9-0.94, 0.95-0.99, and ≥1.0 mmol/L using weighted multivariate-adjusted Cox proportional hazards models.
During a median follow-up of 28.6 years, 9012 deaths occurred, including 3959 CVD deaths, 1923 cancer deaths, and 708 stroke deaths. The multivariate-adjusted HRs (95% CIs) of all-cause mortality across increasing categories of Mg were 1.34 (1.02, 1.77), 0.94 (0.75, 1.18), 1.08 (0.97, 1.19), 1.00 (referent), 1.05 (0.95, 1.16), 0.96 (0.79, 1.15), and 0.98 (0.76, 1.26). Similar trends were observed for cancer (HRs for serum Mg < 0.7: 1.39, 95% CI: 0.83, 2.32) and CVD mortality (HRs for serum Mg < 0.7: 1.28, 95% CI: 0.81, 2.02) but were not statistically significant. An elevated risk for stroke mortality was observed among participants with serum Mg < 0.70 mmol/L (HR: 2.55, 95% CI: 1.18, 5.48).
Very low serum Mg concentrations were significantly associated with an increased risk of all-cause mortality in US adults.
很少有研究在具有代表性的美国成年人样本中，检查血清镁（Mg）浓度与全因和特定原因死亡率之间的关系。我们在一个大型的、具有代表性的美国成年人样本中，研究了基线血清 Mg 浓度与死亡率风险之间的剂量反应关系。
我们分析了来自国家健康与营养检查调查 I 流行病学随访研究（NHEFS）的 14353 名年龄在 25-74 岁之间的参与者的前瞻性数据，这些参与者在基线（1971-1975 年）时测量了血清 Mg 浓度。通过截至 2011 年 12 月 31 日的链接获取死亡率数据。我们使用加权多变量调整 Cox 比例风险模型，估计了血清 Mg 浓度<0.7、0.7-0.74、0.75-0.79、0.8-0.89（参考）、0.9-0.94、0.95-0.99 和≥1.0 mmol/L 各分类内的死亡率风险比（HR）。
在中位随访 28.6 年期间，发生了 9012 例死亡，包括 3959 例心血管疾病死亡、1923 例癌症死亡和 708 例中风死亡。随着 Mg 浓度分类的增加，全因死亡率的多变量调整 HR（95%CI）分别为 1.34（1.02，1.77）、0.94（0.75，1.18）、1.08（0.97，1.19）、1.00（参考）、1.05（0.95，1.16）、0.96（0.79，1.15）和 0.98（0.76，1.26）。对于癌症（血清 Mg <0.7 时的 HR：1.39，95%CI：0.83，2.32）和心血管疾病死亡率（血清 Mg <0.7 时的 HR：1.28，95%CI：0.81，2.02）也观察到类似的趋势，但无统计学意义。血清 Mg <0.70 mmol/L 的参与者中风死亡率升高（HR：2.55，95%CI：1.18，5.48）。
极低的血清 Mg 浓度与美国成年人全因死亡率的增加显著相关。
