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心包主动脉瓣的血流动力学:当代带支架瓣膜与无支架瓣膜的匹配比较

Hemodynamics of Pericardial Aortic Valves: Contemporary Stented versus Stentless Valves in a Matched Comparison.

作者信息

Christ Torsten, Holinski Sebastian, Zhigalov Konstantin, Zielinski Christina Barbara, Grubitzsch Herko

机构信息

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Cardiovascular Surgery, Berlin, Germany.

出版信息

Ann Thorac Cardiovasc Surg. 2017 Dec 20;23(6):298-303. doi: 10.5761/atcs.oa.17-00061. Epub 2017 Sep 8.

Abstract

PURPOSE

Hemodynamic performance of aortic valve bioprostheses is essential for reliable function and durability. So far, the supra-annularly implanted stentless Sorin Freedom Solo (SFS) demonstrated unsurpassed hemodynamic properties. As contemporary stented and externally mounted pericardial bioprostheses, like the Labcor Dokimos Plus (LDP), also improve hemodynamic performance, these types of valves were compared in this study.

METHODS

A total of 218 patients, who underwent aortic valve replacement with the LDP or the SFS, were matched retrospectively 1:1 on variables affecting hemodynamic measurements: implanted valve size, age, sex, and body surface area (BSA). With matching tolerance for valve size and gender of 0%, for age and BSA of 5%, 57 patient-pairs were yielded. Operative data, clinical, and hemodynamic outcome were analyzed.

RESULTS

Except for slightly higher left ventricular function and lower procedural times in the SFS group, preoperative, operative, and postoperative characteristics of patient-pairs did not differ significantly. Mean pressure gradients, effective orifice areas (EOAs), and indexed EOAs were comparable. Corresponding to valve sizes of 21, 23, 25, and 27 mm, the indexed EOAs of the LDP and SFS prostheses were 1.08 ± 0.33, 0.92 ± 0.19, 0.93 ± 0.24, 0.99 ± 0.13 cm/m and 0.81 ± 0.13, 0.92 ± 0.28, 0.95 ± 0.20, 1.04 ± 0.27 cm/m, respectively.

CONCLUSION

Contemporary stented and stentless pericardial bioprostheses showed excellent hemodynamic properties without significant differences in EOAs and indexed EOAs.

摘要

目的

主动脉瓣生物假体的血流动力学性能对于可靠的功能和耐久性至关重要。到目前为止,瓣环上植入的无支架索林自由单瓣(SFS)展现出了无与伦比的血流动力学特性。由于当代有支架和外部安装的心包生物假体,如Labcor Dokimos Plus(LDP),也能改善血流动力学性能,本研究对这些类型的瓣膜进行了比较。

方法

共有218例行LDP或SFS主动脉瓣置换术的患者,根据影响血流动力学测量的变量进行回顾性1:1匹配:植入瓣膜大小、年龄、性别和体表面积(BSA)。瓣膜大小和性别的匹配公差为0%,年龄和BSA的匹配公差为5%,得到57对患者。分析手术数据、临床和血流动力学结果。

结果

除SFS组左心室功能略高和手术时间较短外,配对患者的术前、术中和术后特征无显著差异。平均压力阶差、有效瓣口面积(EOA)和指数化EOA相当。对应于21、23、25和27mm的瓣膜大小,LDP和SFS假体的指数化EOA分别为1.08±0.33、0.92±0.19、0.93±0.24、0.99±0.13cm/m²和0.81±0.13、0.92±0.28、0.95±0.20、1.04±0.27cm/m²。

结论

当代有支架和无支架心包生物假体均显示出优异的血流动力学特性,EOA和指数化EOA无显著差异。

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