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尼日利亚儿童中的青紫型先天性心脏病

Cyanotic congenital heart diseases among Nigerian children.

作者信息

Animasahun Barakat Adeola, Madise-Wobo Akpoembele Deborah, Kusimo Olusola Yejide

机构信息

Department of Pediatrics and Child Health, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.

Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.

出版信息

Cardiovasc Diagn Ther. 2017 Aug;7(4):389-396. doi: 10.21037/cdt.2017.06.03.

Abstract

BACKGROUND

There are only few reports on cyanotic congenital heart diseases (CCHD) among Nigerian and African Children. The current report aim to provide the most recent hospital based data on the distribution of CCHD in children less than 14 years of age, the demographic characteristics and risk factors identified.

METHODS

Prospective and cross-sectional involving consecutive cases of CCHD diagnosed with echocardiography at the Lagos State University Teaching Hospital between January 2007 and June 2016. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Level of significance set at P<0.05.

RESULTS

There were 352 subjects with CCHD with a male to female ratio of 1.34:1. The children were age 2 days to 14 years with a mean ± SD of 38.62±44.74 months and median of 21 months. The most common type of CCHD (both isolated and multiple CCHD) was tetralogy of Fallot (TOF) followed double outlet right ventricle (DORV) and transposition of the great arteries (TGA). The most common mode of presentation was cyanosis.

CONCLUSIONS

TOF was found in almost half of the subjects. Cases of DORV which have been rarely reported were more than those with TGA. Most were diagnosed late. Cyanosis was the most common mode of presentation. Clinical features are protean; thus a high index of suspicion is required to make an early diagnosis.

摘要

背景

关于尼日利亚和非洲儿童中青紫型先天性心脏病(CCHD)的报道较少。本报告旨在提供基于医院的最新数据,内容涉及14岁以下儿童CCHD的分布情况、人口统计学特征及已确定的危险因素。

方法

本研究为前瞻性和横断面研究,纳入2007年1月至2016年6月期间在拉各斯州立大学教学医院经超声心动图诊断为CCHD的连续病例。使用社会科学统计软件包(SPSS)20版进行数据分析。显著性水平设定为P<0.05。

结果

共有352例CCHD患者,男女比例为1.34:1。患儿年龄为2天至14岁,平均±标准差为38.62±44.74个月,中位数为21个月。最常见的CCHD类型(包括单纯型和复合型CCHD)是法洛四联症(TOF),其次是右心室双出口(DORV)和大动脉转位(TGA)。最常见的表现方式是青紫。

结论

几乎一半的患者为TOF。此前鲜有报道的DORV病例比TGA病例更多。大多数患者诊断较晚。青紫是最常见的表现方式。临床特征多样,因此需要高度怀疑才能早期诊断。

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Cardiology patient page. Tetralogy of Fallot.心脏病患者页面。法洛四联症。
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