Particle Technology Laboratory, Department of Mechanical and Process Engineering, Eidgenössische Technische Hochschule Zürich , CH-8092 Zürich, Switzerland.
Department of Pulmonology, University Hospital Zürich , CH-8091 Zürich, Switzerland.
Anal Chem. 2017 Oct 3;89(19):10578-10584. doi: 10.1021/acs.analchem.7b02843. Epub 2017 Sep 22.
Obesity is a global health threat on the rise, and its prevalence continues to grow. Yet suitable biomedical sensors to monitor body fat burn rates in situ, to guide physical activity or dietary interventions toward efficient weight loss, are missing. Here, we introduce a compact and inexpensive breath acetone sensor based on Si-doped WO nanoparticles that can accurately follow body fat burn rates in real time. We tested this sensor on 20 volunteers during exercise and rest and measured their individual breath acetone concentrations in good agreement with benchtop proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS). During exercise, this sensor reveals clearly the onset and progression of increasing breath acetone levels that indicate intensified body fat metabolism, as validated by parallel venous blood β-hydroxybutyrate (BOHB) measurements. Most importantly, we found that the body fat metabolism was especially pronounced for most volunteers during fasting for 3 h after exercise, with strong variation between subjects, and this was displayed correctly by the sensor in real-time. As a result, this simple breath acetone sensor enables easily applicable and hand-held body fat burn monitoring for personalized and immediate feedback on workout effectiveness that can guide dieting as well.
肥胖是一个日益严重的全球健康威胁，其患病率持续上升。然而，目前仍缺乏合适的生物医学传感器来实时监测体内脂肪燃烧率，以指导体育活动或饮食干预，从而实现有效的减肥效果。在这里，我们介绍了一种基于掺硅 WO 纳米粒子的紧凑且廉价的呼吸丙酮传感器，该传感器可以准确实时地跟踪体脂燃烧率。我们在 20 名志愿者进行运动和休息时测试了该传感器，并通过与台式质子转移反应飞行时间质谱 (PTR-TOF-MS) 测量的个体呼吸丙酮浓度进行了很好的比较。在运动过程中，该传感器清楚地揭示了呼吸丙酮水平的升高，表明脂肪代谢增强，这与静脉血β-羟基丁酸 (BOHB) 测量结果一致。最重要的是，我们发现大多数志愿者在运动后禁食 3 小时期间的体脂代谢尤其明显，个体之间存在很大差异，而传感器可以实时正确地显示这种情况。因此，这种简单的呼吸丙酮传感器可以实现易于应用和手持的体脂燃烧监测，为运动效果提供个性化和即时的反馈，从而指导节食。
