Department of Immunology, School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, China.
Clinical Laboratory of Kunshan First People's Hospital Affiliated to Jiangsu University, Suzhou, China.
Biomark Med. 2017 Sep;11(9):741-749. doi: 10.2217/bmm-2017-0078. Epub 2017 Sep 11.
Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance.
PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up.
Downregulation of PD-1 acted as an indicator for GDM occurrence in the third trimester of pregnancy. With the recovery of GDM, PD-1 expression restored to normal level.
PD-1 expression on T-cell subsets is a novel biomarker for the occurrence and recovery of GDM.
越来越多的证据表明，妊娠期间对母婴相互作用的挑战可能导致免疫止血功能受损，并导致妊娠糖尿病（GDM）的发生。免疫检查点分子 PD-1 是平衡免疫反应和免疫耐受的关键分子之一。
通过流式细胞术分析检测 GDM 患者和对照组 T 细胞亚群上 PD-1 的表达，并进行随访。
PD-1 的下调可作为妊娠晚期 GDM 发生的指标。随着 GDM 的恢复，PD-1 的表达恢复正常水平。
T 细胞亚群上 PD-1 的表达是 GDM 发生和恢复的新型生物标志物。
