Hu Yue, Chen Zhou, Zhang He, Li Mingkai, Hou Zheng, Luo Xiaoxing, Xue Xiaoyan
a Department of Pharmacology , Fourth Military Medical University , Xi'an , China.
b Student Brigade , Fourth Military Medical University , Xi'an , China.
Drug Deliv. 2017 Nov;24(1):1295-1301. doi: 10.1080/10717544.2017.1373166.
Nanocarriers of drugs have attracted significant attention to tackle the problems of drug resistance or nucleic acid drug delivery, which can optimize pharmaceutical parameters and enhance the cellular uptake efficiency. Nowadays, DNA nanostructure presents an opportunity in the field of nanomaterial due to its precise control in shape and size, excellent biocompatibility, as well as multiple sites for targeting decoration. DNA tetrahedron, which is stable and easily synthesized, is used for various applications, including nuclear magnetic resonance imaging, molecular diagnosis, targeting drug delivery, and so on. In this review, we will discuss the applications of DNA tetrahedron about drug delivery, intracellular routes and its fates. Also challenges and possible solutions for developing DNA tetrahedron-based drug delivery system are detailed.
药物纳米载体已引起人们的广泛关注，以解决耐药性或核酸药物递送问题，其可以优化药物参数并提高细胞摄取效率。如今，DNA纳米结构因其在形状和尺寸上的精确控制、优异的生物相容性以及多个用于靶向修饰的位点，在纳米材料领域展现出机遇。DNA四面体结构稳定且易于合成，可用于多种应用，包括核磁共振成像、分子诊断、靶向药物递送等。在本综述中，我们将讨论DNA四面体在药物递送、细胞内途径及其命运方面的应用。同时，还详细阐述了开发基于DNA四面体的药物递送系统所面临的挑战及可能的解决方案。
