Cacha L A, Ali J, Rizvi Z H, Yupapin P P, Poznanski R R
Laser Centre, Ibnu Sina ISIR, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia.
J Integr Neurosci. 2017;16(4):493-509. doi: 10.3233/JIN-170038.
Using steady-state electrical properties of non-ohmic dendrite based on cable theory, we derive electrotonic potentials that do not change over time and are localized in space. We hypothesize that clusters of such stationary, local and permanent pulses are the electrical signatures of enduring memories which are imprinted through nonsynaptic plasticity, encoded through epigenetic mechanisms, and decoded through electrotonic processing. We further hypothesize how retrieval of an engram is made possible by integration of these permanently imprinted standing pulses in a neural circuit through neurotransmission in the extracellular space as part of conscious recall that acts as a guiding template in the reconsolidation of long-term memories through novelty characterized by uncertainty that arises when new fragments of memories reinstate an engram by way of nonsynaptic plasticity that permits its destabilization. Collectively, these findings seem to reinforce this hypothesis that electrotonic processing in non-ohmic dendrites yield insights into permanent electrical signatures that could reflect upon enduring memories as fragments of long-term memory engrams.
基于电缆理论，利用非欧姆性树突的稳态电学特性，我们推导出不随时间变化且在空间上局域化的电紧张电位。我们假设，这类静止、局部且永久的脉冲簇是持久记忆的电信号特征，这些记忆通过非突触可塑性被印记，通过表观遗传机制进行编码，并通过电紧张处理进行解码。我们进一步假设，作为有意识回忆的一部分，通过细胞外空间中的神经传递，将这些永久印记的驻留脉冲整合到神经回路中，如何使得记忆印迹的检索成为可能，而有意识回忆在长期记忆的重新巩固中充当指导模板，其特征在于当新的记忆片段通过允许其去稳定化的非突触可塑性恢复记忆印迹时产生的不确定性。总体而言，这些发现似乎强化了这一假设，即非欧姆性树突中的电紧张处理能够深入了解永久电信号特征，这些特征可能反映作为长期记忆印迹片段的持久记忆。
