Llona-Minguez Sabin, Throup Adam, Steiner Emilie, Lightowler Molly, Van der Haegen Sandra, Homan Evert, Eriksson Lars, Stenmark Pål, Jenmalm-Jensen Annika, Helleday Thomas
Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Org Biomol Chem. 2017 Sep 26;15(37):7758-7764. doi: 10.1039/c7ob02069d.
Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.
