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[大动脉炎的中医治法及方剂应用举隅]

[Medicinal laws and application examples of traditional Chinese medicine prescriptions for multiple aorto-arteritis].

作者信息

Zhang Xin-Gen, Cai Hai-Ying

机构信息

Armed Police Beijing Corps Hospital in Beijing, Beijing 100027.

Beijing Dongcheng District Yongdingmenwai Community Health Service Center, Beijing 100075, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2016 May;41(9):1754-1758. doi: 10.4268/cjcmm20160929.

Abstract

To collect the literature on traditional Chinese medicine treatment for multiple aorto-arteritis from China National Knowledge Infrastructure(CNKI), establish prescriptions database after screening and normalizing the prescriptions reported in these literature, and analyze their medicinal rules by using traditional Chinese medicine inheritance support system. A total of 126 prescriptions for multiple aorto-arteritis were screened, containing 212 kinds of Chinese herbs. 26 core herb combinations were obtained by analysis of the commonly used herbs and their use frequencies. The treatment for multiple aorto-arteritis was manly of tonifying qi to nourish blood, promoting blood circulation to remove blood stasis, warming yang to dredge collaterals, and four new prescriptions were obtained. On this basis, two clinical cases were taken as the examples by analyzing the medicinal rules and the features of multiple aorto-arteritis. The first case showed that the herb combination of this study conformed to the basic core drug application mode and the core pathogenesis of multiple aorto-arteritis. The second case reflected the characteristics of the new prescriptions' herb combinations based on entropy hierarchical clustering. The practical analysis of the two clinical cases further indicated the reliability of the results. This study has certain guiding significance and reference value on new medicine research and development as well as clinical traditional Chinese medicine treatment for multiple aorto-arteritis.

摘要

通过中国知网(CNKI)收集中医药治疗多发性大动脉炎的文献,对文献中报道的方剂进行筛选和规范化处理后建立方剂数据库,并运用中医传承辅助系统分析其用药规律。共筛选出126首治疗多发性大动脉炎的方剂,包含212味中药。通过对常用药物及其使用频次分析,得到26个核心药对组合。多发性大动脉炎的治疗以益气养血、活血化瘀、温阳通络为主,并得出4首新方剂。在此基础上,以2例临床病例为例,分析用药规律及多发性大动脉炎的特点。第1例病例表明本研究的药对组合符合多发性大动脉炎的基本核心用药模式及核心病机。第2例病例体现了基于熵层次聚类的新方剂药对组合特点。2例临床病例的实证分析进一步表明结果的可靠性。本研究对多发性大动脉炎新药研发及临床中医治疗具有一定的指导意义和参考价值。

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