Sun Zhi-Xin, Zhang Pan-Pan, Gao Wu-Lin, Dai Guo-Hua
Shandong University of Traditional Chinese Medicine, Ji'nan 250014, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan 250012, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jan;42(2):385-389. doi: 10.19540/j.cnki.cjcmm.20161222.050.
To analyze the prescription and medication rules of Chinese medicines in the treatment of palpitations in the Chinese journal full text database(CNKI) by using traditional Chinese medicine inheritance system, and provide a reference for further research and development of modern traditional Chinese medicines(TCMs) in treatment of palpitations. In order to give better guidance for clinical mediation, prescriptions used for treatment of palpitations in CNKI were collected, and then were input to the TCM inheritance support system for establishing a Chinese medicine prescription database for palpitations. The software's revised mutual information, complex system entropy clustering and other data mining methods were adopted to analyze the prescriptions according to the frequencies of herbs, "four natures", "five flavors" and "meridians" of the high-frequency medicines in the database, identify the core herbs and application characteristics, and analyze the prescription rules and medication experience. Totally, 545 prescriptions used for palpitation were included in this study and involved 247 Chinese herbs. The analysis results showed that the herbs in prescriptions for palpitation mostly had the warm property, and the herbs in heart and spleen meridian accounted for a larger proportion, indicating that the treatment was mainly to nourish heart and strengthen spleen. The top 11 herbs in usage frequency were consistent with the high-frequency medicines in medication patterns of common herbal pairs; therefore, we considered that these 11 herbs were the core herbs; the core herbal combination included Cassia Twig, Licorice, fossil fragments, Ostreae decoction, and evolved into 9 new prescriptions for treating palpitation. Our results objectively presented the prescription and medication rules for treating palpitation and provided extremely effective guidance for the clinical therapy.
运用中医传承辅助系统，分析中国期刊全文数据库（CNKI）中治疗心悸的中药处方及用药规律，为现代中药治疗心悸的进一步研发提供参考。为更好地指导临床用药，收集CNKI中治疗心悸的处方，输入中医传承辅助系统，建立心悸的中药处方数据库。采用软件的修正互信息、复杂系统熵聚类等数据挖掘方法，依据数据库中高频药物的药味、“四气”、“五味”及“归经”频次分析处方，识别核心药物及用药特点，分析处方规律及用药经验。本研究共纳入545首治疗心悸的处方，涉及247味中药。分析结果显示，治疗心悸的处方用药多为温性，归心脾经的药物占比更大，提示治疗以养心健脾为主。用药频次排名前11的药物与常用药对用药规律中的高频药物一致，故认为这11味药物为核心药物；核心药组包括桂枝、甘草、龙骨、牡蛎汤，并演化出9首治疗心悸的新处方。研究结果客观呈现了治疗心悸的处方及用药规律，为临床治疗提供了极具价值的指导。
