a Division of Psychology and Language Sciences , University College London , London , UK.
b The PTSD Research and Treatment Program , Columbia University , New York , NY , USA.
World J Biol Psychiatry. 2019 Apr;20(4):289-300. doi: 10.1080/15622975.2017.1376114. Epub 2017 Oct 5.
To determine the main and interactive effects of four polymorphisms (rs9296158, rs3800373, rs1360780 and rs9470080), childhood abuse and attachment style in predicting severity of PTSD symptoms in two independent, nationally representative samples of US military veterans. Data were analysed from two independent samples of European-American US military veterans who participated in the National Health and Resilience in Veterans Study ( = 1,585 and 577 respectively). Results revealed that carriage of two minor alleles, childhood abuse and insecure attachment style were associated with greater severity of PTSD symptoms. Gene × environment interactions were also observed, with the interaction of homozygous minor allele carriage and history of childhood abuse associated with greater severity of PTSD symptoms; however, these effects were fully counteracted by secure attachment style. Results of this study build on prior work demonstrating a gene × environment interaction between polymorphisms and childhood abuse in predicting risk for PTSD by suggesting that attachment style may moderate this effect. This study has implications for prevention and treatment efforts designed to promote a secure attachment style in veterans with high-risk genotypes and childhood abuse histories.
为了确定四个多态性（rs9296158、rs3800373、rs1360780 和 rs9470080）、儿童期虐待和依恋风格在预测两个独立的、具有全国代表性的美国退伍军人 PTSD 症状严重程度方面的主要和交互作用，本研究对来自两个独立的欧洲裔美国退伍军人样本进行了数据分析，这些退伍军人参与了国家健康和退伍军人复原力研究（分别为 1585 人和 577 人）。结果表明，携带两种次要等位基因、儿童期虐待和不安全的依恋风格与 PTSD 症状的严重程度相关。还观察到基因与环境的相互作用，纯合子携带的次要等位基因和儿童期虐待史与 PTSD 症状的严重程度相关，但这些影响被安全的依恋风格完全抵消。这项研究的结果建立在先前的工作基础上，该工作表明，多态性与儿童期虐待之间的基因与环境相互作用可预测 PTSD 的风险，这表明依恋风格可能会调节这种影响。本研究对旨在促进具有高危基因型和儿童期虐待史的退伍军人形成安全依恋风格的预防和治疗工作具有重要意义。
