Dorian C, Catroux P, Cambar J
Groupe d'Etude de Physiologie et Physiopathologie Rénales, Faculté de Pharmacie de Bordeaux.
Pathol Biol (Paris). 1987 Jun;35(5 Pt 2):735-8.
We have studied the chrononephrotoxicity of amikacin during and after a prolonged treatment in rats. Animals received by intramuscular route a daily dose of 400 mg/kg during 7 days at four different times (08:00, 14:00, 20:00 or 02:00). Large time-dependent variations in renal injury had been evidenced by several parameters and particularly by enzymuria. This injury is maximal when administration is made at 14:00. These data confirmed results obtained in previous investigations. The knowledge of chrononephrotoxicity could permit an optimization of drugs in clinics.
我们研究了阿米卡星在大鼠长期治疗期间及之后的时辰性肾毒性。动物在四个不同时间点（08:00、14:00、20:00或02:00）连续7天通过肌肉注射途径接受每日400mg/kg的剂量。几个参数，特别是酶尿，已证明肾损伤存在很大的时间依赖性变化。当在14:00给药时，这种损伤最大。这些数据证实了先前研究中获得的结果。时辰性肾毒性的知识可能有助于临床药物的优化。
