Dorian C, Catroux P, Cambar J
Groupe d'Etude de Physiologie et Physiopathologie Rénales Faculté de Pharmacie, Bordeaux.
Pathol Biol (Paris). 1989 Jun;37(5 Pt 2):649-51.
We have studied the chrononephrotoxicity of amikacin during and after a prolonged treatment in rats. Animals received by intramuscular route a daily dose of 400 mg/kg (in two times) during 7 days at two different times (8.00 - 20.00 and 14.00 - 2.00). Large time-dependent variations in renal injury had been evidenced by several parameters and particularly by enzymuria. This injury is maximal when administration is made at 14.00 - 2.00. These data confirmed our results obtained in previous investigations with single daily injections and evidence that chrononephrotoxicity could permit an optimization of nephrotoxic drugs largely used in clinics.
我们研究了阿米卡星在大鼠长期治疗期间及之后的时辰性肾毒性。动物在两个不同时间段（8:00 - 20:00和14:00 - 2:00）内，通过肌肉注射途径连续7天每日给予400 mg/kg剂量（分两次给药）。几个参数，特别是酶尿，已证明肾损伤存在较大的时间依赖性变化。当在14:00 - 2:00给药时，这种损伤最大。这些数据证实了我们之前单次每日注射研究中获得的结果，并表明时辰性肾毒性可使临床上大量使用的肾毒性药物得到优化。
