Culley Deborah J, Flaherty Devon, Fahey Margaret C, Rudolph James L, Javedan Houman, Huang Chuan-Chin, Wright John, Bader Angela M, Hyman Bradley T, Blacker Deborah, Crosby Gregory
From the Harvard Medical School, Boston, Massachusetts (D.J.C., D.F., J.L.R., H.J., A.M.B., B.T.H., D.B., G.C.); Departments of Anesthesiology, Perioperative and Pain Medicine (D.J.C., D.F., M.C.F., C.-C. H., A.M.B., G.C.), Medicine (J.L.R., H.J.), Orthopedic Surgery (J.W.), Brigham and Women's Hospital, Boston, Massachusetts; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (B.T.H.); Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts (D.B.); and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (D.B.).
Anesthesiology. 2017 Nov;127(5):765-774. doi: 10.1097/ALN.0000000000001859.
The American College of Surgeons and the American Geriatrics Society have suggested that preoperative cognitive screening should be performed in older surgical patients. We hypothesized that unrecognized cognitive impairment in patients without a history of dementia is a risk factor for development of postoperative complications.
We enrolled 211 patients 65 yr of age or older without a diagnosis of dementia who were scheduled for an elective hip or knee replacement. Patients were cognitively screened preoperatively using the Mini-Cog and demographic, medical, functional, and emotional/social data were gathered using standard instruments or review of the medical record. Outcomes included discharge to place other than home (primary outcome), delirium, in-hospital medical complications, hospital length-of-stay, 30-day emergency room visits, and mortality. Data were analyzed using univariate and multivariate analyses.
Fifty of 211 (24%) patients screened positive for probable cognitive impairment (Mini-Cog less than or equal to 2). On age-adjusted multivariate analysis, patients with a Mini-Cog score less than or equal to 2 were more likely to be discharged to a place other than home (67% vs. 34%; odds ratio = 3.88, 95% CI = 1.58 to 9.55), develop postoperative delirium (21% vs. 7%; odds ratio = 4.52, 95% CI = 1.30 to 15.68), and have a longer hospital length of stay (hazard ratio = 0.63, 95% CI = 0.42 to 0.95) compared to those with a Mini-Cog score greater than 2.
Many older elective orthopedic surgical patients have probable cognitive impairment preoperatively. Such impairment is associated with development of delirium postoperatively, a longer hospital stay, and lower likelihood of going home upon hospital discharge.
美国外科医师学会和美国老年医学会建议,应对老年外科患者进行术前认知筛查。我们推测,无痴呆病史患者中未被识别的认知障碍是术后并发症发生的一个危险因素。
我们纳入了211例65岁及以上、未诊断为痴呆且计划进行择期髋关节或膝关节置换术的患者。术前使用简易认知筛查量表(Mini-Cog)对患者进行认知筛查,并使用标准工具或查阅病历收集人口统计学、医学、功能以及情感/社会数据。结局指标包括出院时未回家(主要结局)、谵妄、住院期间的医疗并发症、住院时间、30天内急诊就诊情况以及死亡率。采用单因素和多因素分析方法对数据进行分析。
211例患者中有50例(24%)简易认知筛查量表筛查结果为可能存在认知障碍(Mini-Cog评分小于或等于2分)。在年龄校正的多因素分析中,与Mini-Cog评分大于2分的患者相比,Mini-Cog评分小于或等于2分的患者出院时未回家的可能性更大(67%对34%;比值比=3.88,95%置信区间=1.58至9.55),发生术后谵妄的可能性更大(21%对7%;比值比=4.52,95%置信区间=1.30至15.68),住院时间更长(风险比=0.63,95%置信区间=0.42至0.95)。
许多老年择期骨科手术患者术前可能存在认知障碍。这种障碍与术后谵妄的发生、更长的住院时间以及出院时回家可能性较低有关。