Lascault G, Fillette F, Grosgogeat Y
Service de Cardiologie, Hôpital de la Salpétrière, Paris.
Presse Med. 1987 Sep 26;16(31):1533-7.
Attempts at preventing total and sudden cardiac death after myocardial infarction can only succeed if its mechanisms and its contributing of determinant factors are known. It is now well established that sudden deaths account for one-half of mortality cases and that in the vast majority of cases these deaths are due to malignant ventricular arrhythmia. Several sudden death risk factors have been identified, including ventricular dysrhythmias, left ventricular dysfunction and myocardial ischaemia. A number of therapeutic trials on the prevention of post-infarction death have been conducted, but so far only beta-blockers have proved effective in reducing the incidence of total and sudden cardiac death. It is permissible to think, however, that other, discerningly selected treatments might also be effective.
只有在了解心肌梗死后心脏性猝死的机制及其决定性因素的情况下，预防心肌梗死后心脏性猝死的尝试才有可能成功。目前已经明确，猝死占死亡病例的一半，并且在绝大多数情况下，这些死亡是由恶性室性心律失常所致。已经确定了一些猝死危险因素，包括室性心律失常、左心室功能障碍和心肌缺血。已经进行了多项预防心肌梗死后死亡的治疗试验，但到目前为止，只有β受体阻滞剂被证明能有效降低心脏性猝死的发生率。然而，可以认为，其他经过精心挑选的治疗方法也可能有效。
