Kanfar Nasreddine, Mehdi Ahmad, Dumy Pascal, Ulrich Sébastien, Winum Jean-Yves
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, ENSCM, Université de Montpellier, 240 avenue du professeur Emile Jeanbrau, 34296, Montpellier Cedex, France.
Institut Charles Gerhardt Montpellier (ICGM), UMR 5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34090, Montpellier, France.
Chemistry. 2017 Dec 19;23(71):17867-17869. doi: 10.1002/chem.201703794. Epub 2017 Oct 4.
The straightforward access to octafunctional "cubic" silsesquioxane platform grafter with pendant glyoxylic aldehydes is described. This clickable hybrid platform readily reacts with oxyamine or hydrazide compounds to provide, respectively, oxime and acylhydrazone conjugates, thereby offering a new and effective access from which one can elaborate multivalent systems for the targeting of biomolecules of interest.
描述了一种直接获得带有侧基乙醛酸醛基的八官能团“立方”倍半硅氧烷平台接枝物的方法。这种可点击的杂化平台能分别与羟胺或酰肼化合物快速反应，生成肟和酰腙共轭物，从而提供了一种新的有效途径，通过该途径可以构建用于靶向感兴趣生物分子的多价体系。
