Darcis G, Moutschen M
Service de Médecine interne et Maladies infectieuses, CHU de Liège,Belgique.
Rev Med Liege. 2017 Sep;72(9):388-392.
More than 30 years after its discovery, human immunodeficiency virus (HIV) continues to be a major global public health issue. Antiretroviral therapy increases survival and quality of life of HIV-infected patients but is not curative. Indeed, interruption of therapy invariably leads to the re-emergence of detectable viral replication, since HIV persists in extremely long-lived viral latent reservoirs. Those viral latent reservoirs constitute the major source of viral recovery following antiretroviral treatment interruption and are considered as the most important hurdle to HIV eradication. Multiple strategies aimed at targeting the HIV latent reservoirs are intensively being explored. We discuss here the most recent innovative works that will hopefully contribute to find a cure for HIV.
在人类免疫缺陷病毒（HIV）被发现30多年后，它仍然是一个重大的全球公共卫生问题。抗逆转录病毒疗法提高了HIV感染患者的生存率和生活质量，但无法治愈。事实上，治疗中断总是会导致可检测到的病毒复制重新出现，因为HIV存在于寿命极长的病毒潜伏库中。这些病毒潜伏库是抗逆转录病毒治疗中断后病毒恢复的主要来源，被认为是根除HIV的最重要障碍。目前正在深入探索多种针对HIV潜伏库的策略。我们在此讨论最新的创新性研究成果，有望为找到治愈HIV的方法做出贡献。
