HIV 潜伏期：我们应该冲击还是锁定？

HIV Latency: Should We Shock or Lock?

机构信息

Service of Molecular Virology, Département de Biologie Moléculaire (DBM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; Service des Maladies Infectieuses, Université de Liège, Centre Hospitalier Universitaire (CHU) de Liège, Domaine Universitaire du Sart-Tilman, B35, 4000 Liège, Belgium.

Service of Molecular Virology, Département de Biologie Moléculaire (DBM), Université Libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.

出版信息

Trends Immunol. 2017 Mar;38(3):217-228. doi: 10.1016/j.it.2016.12.003. Epub 2017 Jan 7.

DOI:10.1016/j.it.2016.12.003

PMID:28073694

Abstract

Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs. Improved understanding of the molecular mechanisms involved in HIV-1 latency has paved the way for innovative strategies that attempt to purge latent virus. In this article we discuss the results of the broadly explored 'shock and kill' strategy, and also highlight the major hurdles facing this approach. Finally, we present recent innovative works suggesting that locking out latent proviruses could be a potential alternative therapeutic strategy.

摘要

联合抗逆转录病毒疗法（cART）提高了 HIV-1 感染患者的生存率和生活质量。然而，治疗中断几乎总是会导致可检测到的病毒复制重新出现，因为 HIV-1 存在于病毒潜伏库中。对 HIV-1 潜伏涉及的分子机制的深入了解为尝试清除潜伏病毒的创新策略铺平了道路。在本文中，我们讨论了广泛探索的“冲击和杀伤”策略的结果，还强调了该方法面临的主要障碍。最后，我们介绍了最近的创新工作，表明锁定潜伏前病毒可能是一种有潜力的替代治疗策略。