青少年肌阵挛性癫痫的基因定位
Mapping genes in juvenile myoclonic epilepsy.
作者信息
Delgado-Escueta A V, Greenberg D A
机构信息
Reed Neurological Research Center, UCLA School of Medicine 90024.
出版信息
Rev Neurol (Paris). 1987;143(5):351-62.
The genetics of the various forms of epilepsy can be best understood by knowing where the affected gene is located. Genetic methodologies used to explore the genetics of epilepsy now include segregation analysis, linkage analysis and recombinant DNA technology. Juvenile myoclonic epilepsy (JME), a form of idiopathic epilepsy with a strong genetic component, provides informative pedigrees for linkage studies. Preliminary results demonstrate the heterogenous nature of the JME syndrome.
通过了解受影响基因的位置，能最好地理解各种形式癫痫的遗传学。目前用于探索癫痫遗传学的基因方法包括分离分析、连锁分析和重组DNA技术。青少年肌阵挛性癫痫（JME）是一种具有很强遗传成分的特发性癫痫，为连锁研究提供了信息丰富的家系。初步结果证明了JME综合征的异质性。
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