Yoshida M, Izumi K, Nakanishi T
Department of Neurology, University of Tsukuba, Ibaraki.
Tohoku J Exp Med. 1987 Jul;152(3):311-7. doi: 10.1620/tjem.152.311.
We investigated effects of TRH on glutamate-induced seizures in rats. Rats were injected intraperitoneally with sodium glutamate in a dose (22.3 mmole/kg) equivalent to ED95 for generalized convulsions. Twenty five min later TRH in a dose of maximum effect (40 micrograms in the tartrate form) was injected intracerebroventricularly in order that the time of peak effect was simultaneous with the onset of seizure which was anticipated from the preliminary study. TRH delayed the onset of initial seizures significantly, though neither occurrence nor incidence of various seizure activities was affected. A trend of delay in the mean time of death was also observed. These results suggest that TRH has an inhibitory action against glutamate-induced seizures in rats, albeit mild.
我们研究了促甲状腺激素释放激素（TRH）对大鼠谷氨酸诱导的癫痫发作的影响。给大鼠腹腔注射相当于全身惊厥ED95剂量（22.3毫摩尔/千克）的谷氨酸钠。25分钟后，为使峰值效应时间与根据初步研究预期的癫痫发作开始时间同步，经脑室注射最大效应剂量（酒石酸盐形式40微克）的TRH。TRH显著延迟了初始癫痫发作的开始，尽管各种癫痫活动的发生和发生率均未受影响。还观察到平均死亡时间有延迟趋势。这些结果表明，TRH对大鼠谷氨酸诱导的癫痫发作具有抑制作用，尽管作用轻微。
