Nikfarjam Masoud, Rakhshan Reza, Ghaderi Hourivash
Assistant Professor, Department of Psychiatry, Islamic Medicine Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
General Practitioner, Student Research Committee, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, I.R. Iran.
J Clin Diagn Res. 2017 Jul;11(7):KC01-KC04. doi: 10.7860/JCDR/2017/20657.10233. Epub 2017 Jul 1.
Major depressive disorder is a chronic disease which may be associated with other mental illnesses. and venlafaxine, herbal and chemical drugs respectively, are used to treat depression. Despite pharmacotherapy, major depressive disorder has a complicated pattern of resistance and recurrence.
The aim of this study was to determine the effect of and venlafaxine in treating depression.
For this study, 120 patients referred to the psychiatry clinic of the Shahrekord University of Medical Sciences, Shahrekord, Iran, were randomly selected. The participants were randomly assigned to three groups: venlafaxine (Control Group), venlafaxine + ( Group), and venlafaxine + placebo (Placebo Group). All the patients underwent treatment for six weeks. Depression test was administered to the three groups at different time intervals before the treatment, four weeks after the treatment and at completion of the treatment. The data were analysed by SPSS version17.0.
Depression scores of all the groups decreased over time (p=0.001). The depression scores were significantly different between the control and groups (p=0.004), and the control and placebo groups (p=0.002), but were not significantly different between the and placebo groups (p=0.95).
Adding or a placebo is equally effective in decreasing mean depression score and venlafaxine obviously decreased this score.
重度抑郁症是一种慢性疾病，可能与其他精神疾病有关。分别使用[药物名称]、文拉法辛、草药和化学药物来治疗抑郁症。尽管进行了药物治疗，但重度抑郁症仍有复杂的耐药和复发模式。
本研究的目的是确定[药物名称]和文拉法辛在治疗抑郁症方面的效果。
在本研究中，随机选择了120名转诊至伊朗沙赫雷克德医科大学精神病学诊所的患者。参与者被随机分为三组：文拉法辛组（对照组）、文拉法辛 + [药物名称]组（[药物名称]组）和文拉法辛 + 安慰剂组（安慰剂组）。所有患者均接受为期六周的治疗。在治疗前、治疗四周后和治疗结束时的不同时间间隔对三组进行抑郁测试。数据采用SPSS 17.0版本进行分析。
所有组的抑郁评分随时间下降（p = 0.001）。对照组与[药物名称]组之间的抑郁评分有显著差异（p = 0.004），对照组与安慰剂组之间也有显著差异（p = 0.002），但[药物名称]组与安慰剂组之间无显著差异（p = 0.95）。
添加[药物名称]或安慰剂在降低平均抑郁评分方面同样有效，且文拉法辛明显降低了该评分。
