原发性高级别涎腺导管癌：一例报告及文献复习
Denovo High Grade Salivary Duct Carcinoma: A Case Report and Review of Literature.
作者信息
Zainab Heena, Sultana Ameena, Jahagirdar Pramod
机构信息
Professor and Head, Department of Oral and Maxillofacial Pathology and Microbiology, Al Badar Rural Dental College and Hospital, Kalaburgi, Karnataka, India.
Postgraduate Student, Department of Oral and Maxillofacial Pathology and Microbiology, Al Badar Rural Dental College and Hospital, Kalaburgi, Karnataka, India.
出版信息
J Clin Diagn Res. 2017 Jul;11(7):ZD10-ZD12. doi: 10.7860/JCDR/2017/29195.10210. Epub 2017 Jul 1.
Salivary Duct Carcinoma (SDC) is a distinctive and clinically aggressive adenocarcinoma of salivary origin. It arises from the ductal epithelium, predominantly occurring in the major salivary glands, especially the parotid gland. Here, we report a case of an extensive salivary gland pathology involving the right side of face, possibly arising from the parotid gland in a 25-year-old male patient. On routine histopathology, the tumour mass revealed a papillary pattern of neoplastic ductal epithelial cells showing comedo-like-central necrosis. Immunohistochemical staining showed tumour cells in the infiltrative component to be diffusely immunopositive for cytokeratin-7 and Her-2, confirming the diagnosis of SDC. This paper presents a case report on salivary duct carcinoma and highlights a review on histological variants of salivary duct carcinoma.
涎腺导管癌（SDC）是一种独特的、具有临床侵袭性的涎腺源性腺癌。它起源于导管上皮，主要发生在大涎腺，尤其是腮腺。在此，我们报告一例25岁男性患者右侧面部广泛的涎腺病变病例，可能起源于腮腺。在常规组织病理学检查中，肿瘤肿块显示肿瘤性导管上皮细胞呈乳头样结构，伴有粉刺样中央坏死。免疫组化染色显示浸润成分中的肿瘤细胞对细胞角蛋白-7和Her-2呈弥漫性免疫阳性，确诊为涎腺导管癌。本文呈现了一例涎腺导管癌的病例报告，并着重对涎腺导管癌的组织学变异进行了综述。
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