苗勒管异常与胎盘早剥的关联：一项荟萃分析。
The association of Mullerian anomalies and placenta abruption: a meta-analysis.
作者信息
Khazaei Salman, Jenabi Ensiyeh, Veisani Yousef
机构信息
a Department of Epidemiology , School of Public Health, Hamadan University of Medical Sciences , Hamadan , Iran.
b Department of Midwifery, Tuyserkan Branch , Islamic Azad University , Tuyserkan , Iran.
出版信息
J Matern Fetal Neonatal Med. 2019 Feb;32(3):512-516. doi: 10.1080/14767058.2017.1379072. Epub 2017 Sep 19.
BACKGROUND
Several epidemiological studies have determined that Mullerian anomalies can increase the risk of placenta abruption. To date, no meta-analysis has been performed for assessing the relationship between placenta abruption and Mullerian anomalies. This meta-analysis was conducted to estimate the association between placenta abruption and Mullerian anomalies.
METHODS
We conducted a computerized literature search in Pubmed, Scopus and Web of Science covering the search period until August 2017. Heterogeneity was recognized by Chi-squared test and the I statistic. The Egger's and Begg's tests were examined for the possibility of publication bias. We carried out a meta-analysis to obtain a summary measure of the association between of placenta abruption and Mullerian anomalies using a random-effects model.
RESULTS
A total of 732 studies was search with 653,146 participants. The overall estimate of OR was 3.10 (95% CI: 1.47, 4.74).
CONCLUSIONS
We reported based on odds ratio reports in epidemiological studies that Mullerian anomalies are a risk factor for placenta abruption.
背景
多项流行病学研究已确定苗勒管异常会增加胎盘早剥的风险。迄今为止，尚未进行过荟萃分析来评估胎盘早剥与苗勒管异常之间的关系。本荟萃分析旨在估计胎盘早剥与苗勒管异常之间的关联。
方法
我们在PubMed、Scopus和Web of Science数据库中进行了计算机化文献检索，检索期截至2017年8月。通过卡方检验和I统计量识别异质性。对Egger检验和Begg检验进行检查以评估发表偏倚的可能性。我们使用随机效应模型进行荟萃分析，以获得胎盘早剥与苗勒管异常之间关联的汇总测量值。
结果
共检索到732项研究，涉及653146名参与者。OR的总体估计值为3.10（95%CI：1.47，4.74）。
结论
基于流行病学研究中的比值比报告，我们报道苗勒管异常是胎盘早剥的一个危险因素。
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