子宫肌瘤与胎盘早剥之间的关联：一项荟萃分析。
The association between uterine leiomyoma and placenta abruption: A meta-analysis.
作者信息
Jenabi Ensiyeh, Ebrahimzadeh Zagami Samira
机构信息
a Department of Midwifery , Tuyserkan Branch, Islamic Azad University , Tuyserkan , Iran.
b Faculty of Midwifery, School of Nursing and Midwifery , Mashhad University of Medical Sciences , Mashhad , Iran.
出版信息
J Matern Fetal Neonatal Med. 2017 Nov;30(22):2742-2746. doi: 10.1080/14767058.2016.1261401. Epub 2016 Nov 29.
BACKGROUND
Some epidemiological studies have found that uterine leiomyoma can increase the risk of placenta abruption. To date, the meta-analysis has not been performed for assessing the relationship between uterine leiomyoma and placenta abruption. This meta-analysis was conducted to estimate the association between uterine leiomyoma and the risk of placenta abruption.
METHODS
A literature search was conducted out in major databases PubMed, Web of Science, and Scopus from the earliest possible year to October 2016. The heterogeneity across studies was explored by Q-test and I statistic. The publication bias was assessed by Begg's and Egger's tests. The results were showed using odds ratio (OR) estimate with its 95% confidence intervals (CI) using a random-effects model.
RESULTS
The literature search included 953 articles until October 2016 with 232,024 participants. Based on OR estimates obtained from case-control and cohort studies, there was significant association between uterine leiomyoma and placenta abruption (2.63; 95% CI: 1.38, 3.88).
CONCLUSIONS
We showed based on reports in observational studies that uterine leiomyoma is a risk factor for placenta abruption.
背景
一些流行病学研究发现子宫肌瘤会增加胎盘早剥的风险。迄今为止，尚未进行荟萃分析来评估子宫肌瘤与胎盘早剥之间的关系。本荟萃分析旨在估计子宫肌瘤与胎盘早剥风险之间的关联。
方法
在主要数据库PubMed、Web of Science和Scopus中从最早年份至2016年10月进行文献检索。通过Q检验和I统计量探讨研究间的异质性。采用Begg检验和Egger检验评估发表偏倚。结果采用随机效应模型，用比值比（OR）估计值及其95%置信区间（CI）表示。
结果
截至2016年10月的文献检索共纳入953篇文章，涉及232,024名参与者。根据病例对照研究和队列研究获得的OR估计值，子宫肌瘤与胎盘早剥之间存在显著关联（2.63；95%CI：1.38，3.88）。
结论
基于观察性研究报告，我们表明子宫肌瘤是胎盘早剥的一个危险因素。
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