Pankrac Joshua, Klein Katja, Mann Jamie F S
Department of Microbiology and Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada.
AIDS Res Ther. 2017 Sep 12;14(1):45. doi: 10.1186/s12981-017-0177-4.
Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of "Kick and Kill" therapies to reverse HIV latency and kick start viral translational activity. This has been done with the aim that concomitant anti-retroviral treatment and the elicited immune responses will prevent de novo infections while eradicating productively infected cells. In this review, we describe our perspective on HIV cure and the new approaches we are undertaking to eradicate the established pro-viral reservoir.
尽管联合抗逆转录病毒疗法在降低HIV病毒血症和挽救生命方面取得了显著成功，但HIV-1感染仍然是一种必须妥善管理的终身感染。对HIV感染过程理解的进展以及其他生物医学领域（如癌症、成像和基因工程）疫苗开发的见解推动了HIV治愈研究的快速发展。在过去几年中，多项研究聚焦于开发“踢杀”疗法，以逆转HIV潜伏状态并启动病毒翻译活性。这样做的目的是，联合抗逆转录病毒治疗和引发的免疫反应将在根除活跃感染细胞的同时预防新感染。在本综述中，我们阐述了我们对HIV治愈的观点以及为根除已建立的前病毒储存库所采用的新方法。
