Aristotle University of Thessaloniki, Thessaloniki, Greece.
IInd Department of Ophthalmology, Aristotle University of Thessaloniki, 56403, Thessaloniki, Greece.
Syst Rev. 2017 Sep 11;6(1):188. doi: 10.1186/s13643-017-0580-x.
Myopia is a common visual disorder with increasing prevalence among developed countries of the world. Myopia constitutes a substantial risk factor for several ocular conditions that can lead to blindness. The purpose of this study is to conduct an overview of systematic reviews and meta-analyses in order to identify and appraise robust research evidence regarding the management of myopia progression in children and adolescents.
A literature search will be conducted in MEDLINE, EMBASE, The Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), and Health Technology Assessment (HTA) Database via Centre for Reviews and Dissemination (CRD). We will search for systematic reviews or meta-analyses that examine optical or pharmaceutical modalities for myopia control. Two independent overview authors will screen the titles and abstracts against the eligibility criteria. Individual study's methodological quality and quality of evidence for each outcome of interest will be assessed by two independent authors using the ROBIS tool and GRADE rating, respectively. In cases of disagreement, consensus will be reached with the help of a third author. Our primary outcomes will be the mean change in refractive error, mean axial length change, and adverse events. A citation matrix will be generated, and the corrected covered area (CCA) will be estimated, in order to identify overlapping primary studies. Possible meta-biases and measures of heterogeneity will be described, and cases of dual co-authorship will be identified and discussed. If any recently published randomized controlled trials (RCTs) are detected, these will be appraised and their findings will be presented. An overall summary of outcomes will be provided using descriptive statistics and will be supplemented by narrative synthesis.
This overview will examine the high level of existing evidence for treatment of myopia progression. Efficient interventions will be identified, and side effects will be reported. The expected benefit is that all robust recent research evidence will be compiled in a single study. The results may inform future research in this area, which should provide insight into the appropriate regimes for the administration of these modalities and contribute to future guideline development.
PROSPERO CRD42017068204.
近视是一种常见的视觉障碍，在世界发达国家中患病率不断上升。近视是导致多种眼部疾病的重要危险因素，这些疾病可导致失明。本研究旨在对系统评价和荟萃分析进行综述，以确定和评估有关儿童和青少年近视进展管理的稳健研究证据。
通过考科蓝中心（CRD）检索 MEDLINE、EMBASE、Cochrane 系统评价数据库（CDSR）、疗效评价文摘数据库（DARE）和卫生技术评估（HTA）数据库，以识别和评估光学或药物治疗近视控制的系统评价或荟萃分析。两名独立的综述作者将根据入选标准筛选标题和摘要。两名独立作者将使用 ROBIS 工具和 GRADE 评级分别评估每个感兴趣结局的研究方法学质量和证据质量。如果存在分歧，将在第三名作者的帮助下达成共识。我们的主要结局将是屈光不正的平均变化、眼轴长度的平均变化和不良事件。将生成引用矩阵，并估计校正后的涵盖面积（CCA），以识别重叠的主要研究。将描述可能的偏倚和异质性度量，并确定和讨论双重合著情况。如果发现任何最近发表的随机对照试验（RCT），将对其进行评估并报告其结果。将使用描述性统计数据提供对结果的总体总结，并通过叙述性综合进行补充。
本综述将检查治疗近视进展的现有证据水平。将确定有效的干预措施，并报告副作用。预期的好处是，将在一项研究中汇总所有最新的稳健研究证据。结果可能为该领域的未来研究提供信息，这将有助于深入了解这些治疗方法的适当管理方案，并为未来指南的制定做出贡献。
PROSPERO CRD42017068204。
