Department of Pathology, General Hospital of Daqing Oil Field, Daqing, P.R. China.
Oncol Res. 2018 May 7;26(4):565-572. doi: 10.3727/096504017X15044461944385. Epub 2017 Sep 6.
Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a regulator of growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa cells. Our results showed that GPC5 was lowly expressed in PCa cell lines. Upregulation of GPC5 significantly inhibited PCa cell proliferation and invasion in vitro as well as attenuated tumor growth in vivo. We also found that overexpression of GPC5 inhibited the epithelial-mesenchymal transition (EMT) and Wnt/β-catenin signaling activation, which was mediated by Sp1. Taken together, we suggest GPC5 as a tumor suppressor in PCa and provide promising therapeutic strategies for PCa.
磷脂酰聚糖 5（GPC5）属于硫酸乙酰肝素蛋白聚糖（HSPGs）家族。它最初被认为是生长因子和形态发生素的调节剂。最近，有报道称其与某些癌症发展过程中的肿瘤发生过程相关。然而，关于其在前列腺癌（PCa）中的确切作用知之甚少。在本研究中，我们探讨了 GPC5 在 PCa 细胞中的表达模式和生物学功能。我们的结果表明，GPC5 在 PCa 细胞系中低表达。GPC5 的上调显著抑制了体外的 PCa 细胞增殖和侵袭，并减弱了体内的肿瘤生长。我们还发现，过表达 GPC5 抑制了上皮-间充质转化（EMT）和 Wnt/β-连环蛋白信号激活，这是由 Sp1 介导的。综上所述，我们认为 GPC5 是 PCa 的肿瘤抑制因子，并为 PCa 提供了有前途的治疗策略。
