Wolff G L, Medina D, Umholtz R L
J Natl Cancer Inst. 1979 Sep;63(3):781-5. doi: 10.1093/jnci/63.3.781.
The time course of appearance of hyperplastic alveolar nodule(s) (HAN) and mammary tumor(s) (MT) was determined in untreated virgin "viable yellow" (Avy/A) and non-yellow (A/a) (C3H/HeNIcrWf X VY/Wf)F1 female mice. The first HAN was detected in a yellow female at age 16 weeks, the first period in which mice were killed. HAN were not found in the non-yellow mice until they were 19 weeks old. The incidence of HAN increased to 92% among yellow females and to 75% among non-yellow females by 36 weeks of age. MT were first observed at age 22 weeks in yellow mice and at 28 weeks in non-yellow mice. The incidence of MT at 36 weeks was 75% among yellow mice and 22% among non-yellow mice. Type B adenocarcinoma was the predominant class of MT found in the yellow mice. The time courses of appearance and incidence of HAN and MT in the non-yellow F1 mice were similar to those observed in inbred C3H female mice. MT first appeared in each population when the incidence of HAN bearers had reached 40--45% regardless of age, body weight, or number of HAN per HAN bearer. Apparently, the phenotypic effects of the Avy gene primarily stimulated the multiplication of nodule-transformed cells to form HAN and thus indirectly enhanced MT formation.
在未经处理的处女“活黄色”（Avy/A）和非黄色（A/a）（C3H/HeNIcrWf×VY/Wf）F1雌性小鼠中，确定了增生性肺泡结节（HAN）和乳腺肿瘤（MT）出现的时间进程。在16周龄时，即在首次处死小鼠的时期，在一只黄色雌性小鼠中检测到首个HAN。非黄色小鼠直到19周龄才发现HAN。到36周龄时，黄色雌性小鼠中HAN的发生率增至92%，非黄色雌性小鼠中增至75%。MT首次在22周龄的黄色小鼠中观察到，在28周龄的非黄色小鼠中观察到。36周时，黄色小鼠中MT的发生率为75%，非黄色小鼠中为22%。B型腺癌是在黄色小鼠中发现的MT的主要类型。非黄色F1小鼠中HAN和MT出现的时间进程及发生率与在近交C3H雌性小鼠中观察到的相似。无论年龄、体重或每个HAN携带者的HAN数量如何，当HAN携带者的发生率达到40%-45%时，MT在每个群体中首次出现。显然，Avy基因的表型效应主要刺激结节转化细胞的增殖以形成HAN，从而间接增强MT的形成。
