Takahashi Y, Sinha D K, Dao T L
J Natl Cancer Inst. 1977 Sep;59(3):1007-12. doi: 10.1093/jnci/59.3.1007.
The chromosome constituents of 101 normal mammary gland cells, 122 hyperplastic alveolar nodule (HAN) cells, and 360 cells from eleven 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the WF rat were examined. Both mammary gland and HAN had normal diploid karyotype patterns, whereas mammary tumors showed frequent (approximately 30%) abnormalities, e.g., aneuploidy, pseudodiploidy, polyploidy, and structural aberrations such as breakage and translocation. These results suggested that chromosome constituents of HAN cells are essentially the same as those of the normal mammary epithelial cells.
对101个正常乳腺细胞、122个增生性肺泡结节（HAN）细胞以及来自11只经7,12 - 二甲基苯并[a]蒽（DMBA）诱导的WF大鼠乳腺肿瘤的360个细胞的染色体组成进行了检查。乳腺和HAN均具有正常的二倍体核型模式，而乳腺肿瘤则频繁出现（约30%）异常，例如非整倍体、假二倍体、多倍体以及诸如断裂和易位等结构畸变。这些结果表明，HAN细胞的染色体组成与正常乳腺上皮细胞基本相同。
