Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Drug Discov Today. 2017 Dec;22(12):1835-1843. doi: 10.1016/j.drudis.2017.09.002. Epub 2017 Sep 8.
Physical characterization of solid form of drug is of paramount importance as its biopharmaceutical properties and/or its processing behavior may be altered. Early identification and monitoring of solid state transformation is a critical requirement for pharmaceutical product development. In combination with chemometrics, a non destructive and non invasive technique like NIR is a powerful tool for solid state characterization. Main focus of this review is application of NIR for qualitative and quantitative analysis of solid forms of drugs and excipients. In addition, this review also sheds light on recent advancement in NIR, such as NIR chemical imaging and NIR based hyphenated techniques.
药物的固体形态的物理特性至关重要，因为其生物药剂学性质和/或加工行为可能会发生改变。早期识别和监测固体状态转变是药物产品开发的关键要求。与化学计量学结合使用，近红外（NIR）等非破坏性、非侵入性技术是用于固体形态表征的有力工具。本文综述的重点是 NIR 在药物和赋形剂的固体形态的定性和定量分析中的应用。此外，本文还介绍了 NIR 的最新进展，如 NIR 化学成像和基于 NIR 的联用技术。
