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受miR-138调控的CREPT促进乳腺癌进展。

CREPT regulated by miR-138 promotes breast cancer progression.

作者信息

Liang Zhi, Feng Qi, Xu Licheng, Li Shuyan, Zhou Lei

机构信息

Department of General Surgery, Yantaishan Hospital, Yantai City, Shandong Province, 264000, PR China.

The 21 Ward of General Surgery, Daqing Oil Field General Hospital, Daqing, Heilongjiang, 163000, China.

出版信息

Biochem Biophys Res Commun. 2017 Nov 4;493(1):263-269. doi: 10.1016/j.bbrc.2017.09.033. Epub 2017 Sep 8.

DOI:10.1016/j.bbrc.2017.09.033
PMID:28893536
Abstract

CREPT (also known as RPRD1B) function as an oncogene and is highly expressed in several kinds of cancers. However, the distribution and clinical significance of CREPT in breast cancer (BC) still not clarified. In this study, we found that the CREPT expression is greatly upregulated in BC tissues and cell lines. Moreover, the CREPT expression was significantly associated with tumor differentiation and metastasis. Next, the functional assay of CREPT showed that CREPT could promote BC proliferation and invasion both in vitro and in vivo. Dual-luciferase reporter assay indicated that miR-138 regulated the expression of CREPT by binding to its 3'-UTR. miR-138 is downregulated and inversely correlated with CREPT expression in BCs. Overexpression of miR-138 suppressed tumor growth and invasion, these effects could be reversed by re-expressing CREPT. Mechanistically, CREPT regulated β-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC.

摘要

CREPT(也称为RPRD1B)作为一种癌基因发挥作用,在多种癌症中高表达。然而,CREPT在乳腺癌(BC)中的分布及临床意义仍未明确。在本研究中,我们发现CREPT在BC组织和细胞系中表达显著上调。此外,CREPT表达与肿瘤分化和转移显著相关。接下来,CREPT的功能分析表明,CREPT在体外和体内均可促进BC增殖和侵袭。双荧光素酶报告基因检测表明,miR-138通过结合其3'-UTR来调节CREPT的表达。在BC中,miR-138表达下调且与CREPT表达呈负相关。miR-138过表达抑制肿瘤生长和侵袭,重新表达CREPT可逆转这些作用。机制上,CREPT在BC中调节β-连环蛋白/TCF4/细胞周期蛋白D1通路。总之,数据表明miR-138/CREPT参与BC进展,为BC提供了潜在的治疗靶点。

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引用本文的文献

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Cancers (Basel). 2025 Jul 19;17(14):2401. doi: 10.3390/cancers17142401.
2
Negative regulation of CD44st by miR-138-5p affects the invasive ability of breast cancer cells and patient prognosis after breast cancer surgery.miR-138-5p 通过负向调控 CD44st 影响乳腺癌细胞的侵袭能力及乳腺癌术后患者的预后。
BMC Cancer. 2023 Mar 24;23(1):269. doi: 10.1186/s12885-023-10738-0.
3
MicroRNA-383: A tumor suppressor miRNA in human cancer.
微小RNA-383:人类癌症中的一种肿瘤抑制性微小RNA。
Front Cell Dev Biol. 2022 Oct 13;10:955486. doi: 10.3389/fcell.2022.955486. eCollection 2022.
4
The role of miR-370 and miR-138 in the regulation of BMP2 suppressor gene expression in colorectal cancer: preliminary studies.miR-370 和 miR-138 在结直肠癌中调控 BMP2 抑制基因表达中的作用:初步研究。
J Cancer Res Clin Oncol. 2022 Jul;148(7):1569-1582. doi: 10.1007/s00432-022-03977-4. Epub 2022 Mar 15.
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Effect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C.微小 RNA-138 通过靶向信号素 4C 对乳腺癌细胞上皮-间充质转化和侵袭的影响。
Bioengineered. 2021 Dec;12(2):10117-10125. doi: 10.1080/21655979.2021.2000733.
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