Giaume Christian, Sáez Juan C, Song Weihong, Leybaert Luc, Naus Christian C
ICIRB, CNRS UMR7241/INSERM, 05, Collège de France, Paris Cedex 05, France.
Departamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago, and Instituto Milenio de Neurociencias de Valparaíso, Chile.
Neurosci Lett. 2019 Mar 16;695:100-105. doi: 10.1016/j.neulet.2017.09.006. Epub 2017 Sep 8.
By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the normal brain, this interaction underlies homeostasis, metabolic supply and neuroprotection. In models of neuroinflammation these channels present aberrant functioning. Validation of the molecular mechanisms by which these membrane channels influence neurodegeneration particularly in Alzheimer's disease could lead to new and alternative therapeutic strategies targeting these channels.
到2040年，神经退行性疾病将成为仅次于心血管疾病的全球第二大死因（世界卫生组织）。需要付出巨大努力来阐明神经退行性疾病潜在的分子和细胞机制。连接蛋白和泛连接蛋白膜通道蛋白是神经元、神经胶质和血管组织相互作用的通道。在正常大脑中，这种相互作用是体内平衡、代谢供应和神经保护的基础。在神经炎症模型中，这些通道会出现功能异常。验证这些膜通道影响神经退行性变，尤其是在阿尔茨海默病中的分子机制，可能会带来针对这些通道的新的替代治疗策略。
